# Navigating Complexity: Transcatheter Aortic Valve Replacement (TAVR) in an Elderly Patient With Critical Aortic Stenosis and Severe Annular Calcification

**Authors:** Nouraldeen Manasrah, Dania Al Jabri, Sarah Alqasem, Ahmed Abdelrahman, Musa Sharkawi

PMC · DOI: 10.7759/cureus.93403 · Cureus · 2025-09-28

## TL;DR

An elderly patient with severe heart valve issues successfully underwent a series of procedures to improve heart function and quality of life.

## Contribution

Demonstrates successful PVL closure using a vascular plug to improve outcomes in TAVR patients with severe calcification.

## Key findings

- TAVR with a 23-mm valve improved ejection fraction but caused a mild to moderate paravalvular leak.
- PVL closure using an 8-mm Amplatzer Vascular Plug II reduced the leak to a trace and improved symptoms.
- The patient remained independent with minimal symptoms eight months post-procedure.

## Abstract

We present the case of a 93-year-old female patient with critical calcific aortic stenosis, severe annular and left ventricular outflow tract (LVOT) calcification, and reduced ejection fraction who underwent transcatheter aortic valve replacement (TAVR) with a 23-mm Edwards Sapien 3 Ultra valve. Post-procedure, she experienced a mild to moderate paravalvular leak (PVL) with an improvement in ejection fraction. At the one-month follow-up, worsening dyspnea and moderate to severe PVL were noted. Percutaneous PVL closure was successfully performed using an 8-mm Amplatzer Vascular Plug II, effectively reducing the leak to a trace. The patient was discharged the following day and remains independent with minimal symptoms at eight months. This case highlights the challenges of managing severe annular calcification during TAVR and the utility of PVL closure to improve clinical outcomes.

## Linked entities

- **Diseases:** aortic stenosis (MONDO:0042981)

## Full-text entities

- **Diseases:** annular and left ventricular outflow tract (LVOT) calcification (MESH:D000092242), calcific (MESH:D002114), Aortic Stenosis (MESH:D001024), PVL (MESH:D019559), dyspnea (MESH:D004417), Annular Calcification (MESH:D016460)
- **Chemicals:** Edwards Sapien 3 (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12570122/full.md

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Source: https://tomesphere.com/paper/PMC12570122