# Exploration of bacteriophage therapy as a viable alternative to combat antibiotic-resistant bacterial infections: A comprehensive in vitro and in vivo evaluation

## TL;DR

This study explores bacteriophage therapy as a safe and effective alternative to antibiotics for treating drug-resistant bacterial infections in lab and animal models.

## Contribution

The study provides a comprehensive in vitro and in vivo evaluation of phage therapy against multidrug-resistant bacterial strains.

## Key findings

- Phage treatment reduced bacteria by up to 4.5 log10 CFU/mL and improved mouse survival rates up to 85%.
- Phage therapy showed synergy with antibiotics and preserved gut microbiota without adverse effects.

## Abstract

Antibiotic resistance in pathogens like E. coli, Klebsiella pneumoniae, and Pseudomonas
aeruginosa poses a major threat to global health, with limited treatment options. This study systematically evaluated the
efficacy of bacteriophage therapy in vitro and in vivo against multidrug-resistant strains. Phage
treatment led to significant bacterial reduction (up to 4.5 log10 CFU/mL) and improved survival rates in mice (up to 85%).
Synergistic effects with antibiotics and preservation of gut microbiota were observed without adverse reactions. These findings
highlight phage therapy as a promising, targeted, and safe alternative for managing resistant infections.