# Seroprevalence of TTIs and its association with ABO and Rh blood groups among blood donors

## TL;DR

This study finds that certain blood groups, like O Negative and B Positive, are linked to higher rates of infections in blood donors, which could help improve blood safety.

## Contribution

The study identifies a significant association between specific ABO/Rh blood groups and higher seroprevalence of transfusion-transmitted infections.

## Key findings

- O Negative blood group had the highest TTI seroprevalence (9.41%) with a significant odds ratio.
- AB Positive blood group showed the lowest TTI seroprevalence (4.28%) with a reduced odds ratio.
- A strong statistical association was confirmed between blood groups and TTI seroprevalence (χ2=53.9, p<0.0001).

## Abstract

Transfusion-transmitted infections (TTIs) such as HIV, HBV, HCV, syphilis, and malaria pose significant risks to blood safety.
Therefore, it is of interest to assess the seroprevalence of TTIs and their association with ABO/Rh blood groups among 30,335 blood
donors. Data from 30,335 donations, with 1,843 reactive units, were analyzed demographically. Overall TTI seroprevalence was 6.08%. O
Negative showed the highest reactive rate (9.41%, OR=1.62, 95% CI: 1.14-2.30), followed by B Positive (7.06%, OR=1.26, 95% CI: 1.14-1.39).
AB Positive had the lowest rate (4.28%, OR=0.66, 95% CI: 0.56-0.78). A significant association was confirmed (χ2=53.9,
df=7, p<0.0001). O Negative and B Positive blood groups are strongly associated with higher TTI seroprevalence, while AB Positive
shows lower risk. Thus, targeted screening for high-risk groups could enhance blood safety.