# Assessment of cardiac autonomic dysfunction in patients with chronic kidney disease using heart rate variability

## TL;DR

This study shows that heart rate variability decreases in chronic kidney disease patients, indicating early cardiovascular risks.

## Contribution

The study introduces HRV analysis as a non-invasive method to assess autonomic dysfunction in CKD patients.

## Key findings

- CKD patients showed significantly reduced HRV and baroreflex sensitivity compared to healthy individuals.
- Autonomic dysfunction worsened with more advanced CKD stages and lower eGFR levels.
- HRV analysis can help identify early cardiovascular risks in CKD patients.

## Abstract

Cardiac autonomic dysfunction has been majorly linked with chronic kidney disease (CKD) and has related this condition to an increase
in cardiovascular risk. This study compared heart rate variability (HRV) and baroreflex sensitivity among 120 patients with CKD and 60
healthy individuals. Patients with CKD exhibited a significant decrease in the HRV parameters and baroreflex sensitivity (p < 0.001).
The more advanced the CKD stage and the worse the eGFR, the worse the autonomic dysfunction. A non-invasive measure referred to as HRV
analysis can be conducted to stratify early cardiovascular risks in CKD.