# Phenotypic detection of multidrug resistance and metallo-β-lactamase production among clinically relevant non-fermenters at a medical centre in India

## TL;DR

This study examines drug-resistant bacteria in India, finding high rates of multidrug resistance and metallo-beta-lactamase production among non-fermenters.

## Contribution

The study provides new insights into the prevalence of MDR and MBL in non-fermenting gram-negative bacilli in a specific Indian medical center.

## Key findings

- 72.8% of isolates showed multidrug resistance.
- 41.2% of strains produced metallo-beta-lactamase.
- Colistin, polymyxin B, and tigecycline showed the highest susceptibility.

## Abstract

Non-fermenting gram-negative bacilli (NFGNB) have become a new vision of serious and clinically important nosocomial infection, with
a growing multidrug resistance (MDR), as well as the production of metallo-beta-lactamase (MBL), which makes their intervention in
tertiary care centres difficult. This 18-month prospective research carried out in Bihar scrutinized 342 NFGNB isolates, whereby the
most dominant was Pseudomonas aeruginosa. MDR was observed in 72.8 percent of isolates and it was significantly higher
in people in the ICU (p < 0.001), whereas MBL was seen in 41.2 percent of strains. The highest susceptibility was shown by colistin,
polymyxin B and tigecycline. Thus, the urgent need for effective antimicrobial stewardship and infection control practices is reported.