# In vitro characterization of drynaria in-situ gel: A novel approach to periodontal disease management

## TL;DR

A new in-situ gel made from Drynaria rhizome extract is being studied for its potential in treating periodontal disease.

## Contribution

The paper introduces a novel Drynaria in-situ gel with temperature-sensitive properties for local drug delivery in periodontal care.

## Key findings

- The Drynaria in-situ gel demonstrates desirable clinical properties like temperature sensitivity and viscosity stability.
- Laboratory studies confirm the gel's uniformity and stability, making it a promising candidate for periodontal drug delivery.
- Further clinical trials are needed to validate its effectiveness in real-world periodontal treatment.

## Abstract

The condition of periodontal diseases that results from oral dysbiosis-related inflammation poses crucial public health concerns.
Therefore, it is of interest to assess an in-situ gel made with Drynaria rhizome extract for local drug application in
periodontal care. The drynaria in-situ gel has desirable clinical properties because its combination of Sodium
Tripolyphosphate (STPP), Poloxamer 407, Acetic Acid and Chitosan produces temperature-sensitive features and viscosity stability.
Studies under laboratory conditions proved both the uniformity and stability of the gel. The tested Drynaria gel
emerges as a promising choice for local drug delivery in periodontal healthcare and researchers need to conduct additional clinical
trials to prove its performance in real-world conditions.