# Review

## TL;DR

This review explores how non-invasive prenatal testing is implemented worldwide, focusing on challenges and solutions in different healthcare systems.

## Contribution

The paper provides global insights and recommendations for ethical and equitable implementation of NIPT.

## Key findings

- NIPT is well-integrated in high-resource settings but limited by cost and regulation in lower-income countries.
- Ethical implementation requires informed consent and equitable access.
- Policy evaluation is crucial for continuous improvement in NIPT adoption.

## Abstract

Non-invasive prenatal testing (NIPT) offers a highly sensitive and specific method for screening fetal chromosomal abnormalities
using cell-free fetal DNA from maternal plasma. This systematic review examined global implementation strategies, highlighting clinical,
ethical and policy-related barriers and facilitators. NIPT is well-integrated in high-resource settings, while cost and regulatory
issues limit access in lower-income countries. Ethical implementation requires informed consent, equitable access and continuous policy
evaluation. Findings provide key recommendations for global healthcare systems integrating NIPT.