# Linking ABO blood group with angle's classification and malocclusion severity in orthodontic patients: A cross-sectional study

**Authors:** Zeeshan Mubashir, Heena Dixit, Akhilesh M., Arti Devi, Subash Ch. Nayak, Dhananjay Rathod, Deepak Sharma

PMC · DOI: 10.6026/973206300212120 · Bioinformation · 2025-07-31

## TL;DR

This study found a link between ABO blood groups and the type and severity of malocclusion in orthodontic patients.

## Contribution

It introduces a novel association between blood groups and malocclusion patterns in orthodontic patients.

## Key findings

- Blood group O had higher prevalence of Class I malocclusion.
- Class II malocclusion was more common in group B.
- Class III malocclusion showed increased occurrence in group A.

## Abstract

ABO blood group antigens, known to play roles beyond immunohematology, may contribute to craniofacial development and dental arch
alignment. A cross-sectional research was conducted among 200 orthodontic patients aged 12-30 years. Blood group O showed a higher
prevalence of Class I malocclusion (48.9%), while Class II was more common in group B (46.3%). Class III showed increased occurrence in
group A (41.7%). A statistically significant association was found between ABO blood group and both malocclusion type (p=0.043) and
severity (p=0.038). ABO blood group may be a predictive marker in malocclusion type and severity.

## Full-text entities

- **Genes:** ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase) [NCBI Gene 28] {aka A3GALNT, A3GALT1, GTA, GTB, NAGAT}
- **Diseases:** malocclusion (MESH:D008310), Class I malocclusion (MESH:D008311)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12569870/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12569870/full.md

---
Source: https://tomesphere.com/paper/PMC12569870