# A typical presentation of AMSAN variant of guillain-barré syndrome in an elderly female with multisystem involvement: A case report

## TL;DR

This case report details an elderly woman with a severe form of Guillain-Barré Syndrome called AMSAN, highlighting the challenges in diagnosis and the importance of early treatment.

## Contribution

The paper presents a rare case of AMSAN in an elderly patient with multisystem involvement, emphasizing diagnostic challenges and management strategies.

## Key findings

- AMSAN in elderly patients can present with rapid progression and multisystem complications.
- Early IVIg treatment did not prevent the need for intensive care in this case.
- MRI and EEG findings were complicated by age-related changes, affecting diagnosis.

## Abstract

Guillain-Barré Syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy, with the AMSAN (Acute Motor and Sensory
Axonal Neuropathy) variant representing a severe subtype characterized by rapid progression and poor prognosis. This report describes a
68-year-old woman presenting with progressive quadriparesis, cranial nerve involvement, and bowel and respiratory complications,
ultimately diagnosed as AMSAN based on nerve conduction studies and cerebrospinal fluid analysis. MRI and EEG findings contributed to
the diagnostic complexity due to age-related degenerative and vascular changes. Despite early IVIg administration, the patient required
intensive care, emphasizing the need for prompt diagnosis and multidisciplinary management. AMSAN in elderly patients demands high
clinical vigilance and early neurophysiological evaluation to initiate timely immunotherapy and improve outcomes.