# Bacterial and host interactions in Staphylococcus aureus-induced septic arthritis—understanding pathogenesis and exploring therapeutic strategies

## TL;DR

This review explores how Staphylococcus aureus causes septic arthritis and examines new treatment strategies to reduce joint damage.

## Contribution

The paper provides a comprehensive overview of bacterial and host interactions in S. aureus-induced septic arthritis and highlights emerging therapeutic approaches.

## Key findings

- S. aureus virulence factors like cell wall components and toxins play a key role in disease progression.
- Host factors such as aging and immune responses significantly influence the severity of septic arthritis.
- Emerging therapies targeting virulence, immune modulation, and bone protection show promise in reducing joint damage.

## Abstract

Septic arthritis is a severe and rapidly destructive joint infection, primarily caused by Staphylococcus aureus. The interplay between bacterial virulence factors and host immune responses determines disease progression and clinical outcomes. This review discusses the key bacterial factors that contribute to septic arthritis, including S. aureus cell wall components, surface proteins, and secreted toxins. In parallel, host-related factors, such as aging, immune responses, and genetic predispositions, are examined in conjunction with the impact of S. aureus infection on bone integrity and osteoimmunological mechanisms. Finally, this review highlights emerging therapeutic approaches, including targeted anti-virulence strategies, immune modulation, and anti-osteoclastogenic interventions, in mitigating joint damage. Understanding the multifaceted interactions between S. aureus and the host immune system is crucial for advancing treatment strategies and reducing morbidity associated with septic arthritis.