# Electroacupuncture and vagus nerve stimulation are emerging therapies for hyperemesis gravidarum management

**Authors:** Shike Zhang, Hui He, Xinyu Li, Yi Guo

PMC · DOI: 10.3389/fneur.2025.1615635 · Frontiers in Neurology · 2025-10-15

## TL;DR

This paper reviews non-traditional therapies like electroacupuncture and vagus nerve stimulation for managing severe nausea and vomiting during pregnancy.

## Contribution

The paper proposes a novel model for HG management through vagus nerve modulation at specific anatomical points.

## Key findings

- Electroacupuncture and vagus nerve stimulation show potential as safe and effective therapies for hyperemesis gravidarum.
- Targeted stimulation at auricular and cervical points may modulate the vagus nerve to alleviate symptoms of NVP/HG.
- A neurophysiological model is introduced to guide future treatment strategies for managing HG.

## Abstract

Hyperemesis gravidarum (HG), an extreme form of nausea and vomiting during pregnancy (NVP), significantly impairs the quality of life of affected individuals. This review examines the multifactorial etiology of the HG and evaluates the efficacy of non-traditional therapeutic approaches, namely, vagus nerve stimulation (VNS) and electroacupuncture. By synthesizing a comprehensive body of literature, we highlight the neurophysiological mechanisms underlying these therapies and propose a novel model for the HG management. The model focuses on vagus nerve modulation through targeted stimulation at the auricular and cervical points, suggesting a promising avenue for effective and safe treatment strategies against the NVP/HG.

## Linked entities

- **Diseases:** hyperemesis gravidarum (MONDO:0006791)

## Full-text entities

- **Diseases:** nausea and vomiting (MESH:D020250), HG (MESH:D006939)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12568412/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12568412/full.md

## References

168 references — full list in the complete paper: https://tomesphere.com/paper/PMC12568412/full.md

---
Source: https://tomesphere.com/paper/PMC12568412