# The Impact of Diet on the Fecal Microbiota Transplantation Success in Patients with Gastrointestinal Diseases—A Literature Review

## TL;DR

This paper reviews how diet affects the success of fecal microbiota transplantation in gastrointestinal diseases.

## Contribution

It identifies that fiber-rich and anti-inflammatory diets enhance FMT effectiveness by supporting gut microbiota diversity and function.

## Key findings

- Increased fiber intake delays loss of transplanted microbiota diversity and improves clinical outcomes after FMT.
- Anti-inflammatory diets combined with FMT may help achieve remission in ulcerative colitis patients.
- Optimal nutrition supports gut microbiota, short-chain fatty acids, and intestinal barrier integrity post-FMT.

## Abstract

Background: Fecal microbiota transplantation (FMT) is a therapeutic method involving the administration of appropriately prepared feces from a healthy donor to the gastrointestinal tract of a recipient. This literature review aims to summarize and critically evaluate the available evidence on the impact of different dietary patterns and nutrients on the efficacy of FMT. Methods: The present literature review focuses on the impact of diet on the gut microbiota in the context of the effectiveness of fecal microbiota transplantation. A literature review was conducted based on the PubMed Database. Results: More and more data confirm the close link between diet and gut microbiota and suggest that proper nutrition before and after FMT may support the effectiveness of this procedure. It appears that increased fiber intake significantly delays the loss of diversity in the transplanted microbiota, thereby enhancing the beneficial clinical effects following FMT. Additionally, the use of an anti-inflammatory components in the diet combination with FMT could be effective in achieving clinical remission in patients with ulcerative colitis. Conclusions: Based on the literature review, it appears that the most optimal nutritional model (through its beneficial effect on the composition of the gut microbiota, short-chain fatty acids production, and intestinal barrier integrity) to support the effectiveness of FMT is an anti-inflammatory diet rich in dietary fiber (for both the donor and the recipient).