# The Role of Nutritional Therapy in the Treatment of Adults with Crohn’s Disease: A Review

**Authors:** Raffaele Li Voti, Fabio Salvatore Macaluso, Elena Banci, Angelo Campanozzi, Giulia D’Arcangelo, Alessia De Blasi, Salvatore Oliva, Elena Sofia Pieri, Sara Renzo, Cosimo Ruggiero, Giusy Russo, Luca Scarallo, Paolo Lionetti, Ambrogio Orlando

PMC · DOI: 10.3390/nu17203186 · Nutrients · 2025-10-10

## TL;DR

Nutritional therapy can help manage Crohn’s disease in adults, especially when combined with partial enteral nutrition and tailored to individual needs.

## Contribution

This review clarifies the emerging role of nutritional therapy in adult Crohn’s disease management alongside conventional treatments.

## Key findings

- Nutritional therapy can induce remission in adults with mild to moderate Crohn’s disease.
- Partial enteral nutrition combined with dietary modifications shows promise in treatment.
- Tailoring diets to cultural preferences and involving dietitians improves outcomes.

## Abstract

Crohn’s disease (CD) is an immune-mediated inflammatory bowel disease (IBD) with a multifactorial pathogenesis involving genetic predisposition, immune dysregulation, and environmental triggers. Dietary patterns have recently garnered growing attention for their potential benefits and risks in patients with IBD. Nutritional therapy has been established as an effective option in pediatric populations, but its role in adults remains less defined. The available studies indicate that while no single diet can be universally recommended, adherence to a Mediterranean diet is associated with multiple health benefits. Nutritional therapy appears promising in inducing clinical remission in adults with mild to moderate CD, particularly when partial enteral nutrition is combined with food-based modifications. Tailoring these strategies to cultural contexts and providing support from qualified dietitians may improve adherence, clinical outcomes, and overall quality of life. This review highlights the growing role of nutritional therapy in adult CD and its potential integration into routine management alongside conventional treatments.

## Linked entities

- **Diseases:** Crohn’s disease (MONDO:0005011), inflammatory bowel disease (MONDO:0005265)

## Full-text entities

- **Diseases:** CD (MESH:D003424), immune (MESH:D007154), IBD (MESH:D015212)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

90 references — full list in the complete paper: https://tomesphere.com/paper/PMC12567425/full.md

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Source: https://tomesphere.com/paper/PMC12567425