# Tumor-Derived Microvesicles Promote Kidney Regeneration and Cytoprotective Immunomodulation

## TL;DR

Tumor-derived microvesicles can help repair damaged kidneys and reduce inflammation, similar to microvesicles from stem cells.

## Contribution

The study shows tumor-derived microvesicles can regenerate kidney tissue and modulate immune responses.

## Key findings

- Tumor-derived and stem cell-derived microvesicles improved kidney function and structure in a mouse model of chronic kidney injury.
- Both types of microvesicles reduced pro-inflammatory T cells and increased regulatory T cells in the spleen.
- Treatment restored normal levels of collecting tubules in the renal medulla.

## Abstract

Background: A comparative study was conducted to evaluate the potential of extracellular, tumor-derived microvesicles (MVs)s in promoting kidney regeneration. Methods: MVs were collected from L929 sarcoma, LLC, and B16 melanoma cells, and mesenchymal stem cells (MSCs). The regenerative activity of MVs was evaluated in an experimental murine model of chronic kidney injury (CKI). Results: Both tumor-derived MVs (T-MVs) and MSC-derived MVs (MSC-MVs) significantly improved kidney function and histological structure. Specifically, the height of collecting tubules in the middle third of the renal medulla returned to normal levels following MV treatment. Both T-MVs and MSC-MVs reduced the proportion of pro-inflammatory CD4+CD44+ T cells in renal cell infiltrates and spleens of CKI mice. Furthermore, treatment with these MVs increased the number of natural CD4+CD25+FoxP3+ regulatory T cells in the spleen, indicating their immunomodulatory effects. Conclusions: These findings suggest that T-MVs, similar to MSC-MVs, possess a universal capacity to promote kidney tissue regeneration and exert anti-inflammatory immunomodulatory effects.