# Centipeda minima: A Review of Phytochemistry, Pharmacology, and Predictive Analysis on Quality Markers

## TL;DR

This paper reviews the chemical composition and medicinal properties of Centipeda minima and proposes potential quality markers for evaluating its quality.

## Contribution

The study predicts and analyzes potential quality markers for Centipeda minima using the Q-Markers concept in Chinese medicine.

## Key findings

- Compounds like brevilin A, arnicolide C, arnicolide D, and helenalin are proposed as candidate Q-Markers for Centipeda minima.
- The study provides a scientific basis for identifying pharmacologically active substances in Centipeda minima.
- Five perspectives are used to predict Q-Markers: botanical phylogeny, chemical specificity, measurability, traditional efficacy, and medicinal properties.

## Abstract

As a traditional Chinese medicinal herb, Centipeda minima (L.) A. Braun & Asch is known for its effects in dispersing wind-cold, clearing nasal passages, and relieving coughs. Current research has identified various chemical constituents isolated from C. minima, including volatile oils, flavonoids, organic acids, and terpenoids. These compounds demonstrate multiple pharmacological activities such as anti-inflammatory, antioxidant, anti-allergic, and anti-tumour effects. This review summarizes the chemical constituents, pharmacological effects, and clinical applications of C. minima. Furthermore, based on the concept of Quality Markers (Q-Markers) in Chinese medicine, potential Q-Markers for C. minima are predicted and analyzed from five perspectives: botanical phylogeny, specificity of chemical composition, measurability of constituents, traditional efficacy, and medicinal properties. Compounds including brevilin A, arnicolide C, arnicolide D, and helenalin are proposed as candidate Q-Markers for C. minima, providing a scientific basis for elucidating its pharmacologically active substances and establishing quality evaluation criteria.