# Enantioselective Preparation of (N,O)-, (N,N)- and (N,S)-Spiroketal Moieties

## TL;DR

This review discusses methods for creating specific spiroketal structures with high enantioselectivity, important in natural products and drugs.

## Contribution

The paper provides a comprehensive overview of enantioselective strategies for synthesizing (N,O)-, (N,N)-, and (N,S)-spiroketal moieties.

## Key findings

- Enantioselective strategies rely on metallo-, organo-, or Lewis acid-catalyzed reactions.
- These methods are effective for constructing spiroketal skeletons found in natural products and pharmaceuticals.

## Abstract

This review highlights enantioselective strategies for preparing (N,O)- (N,N)- and (N,S)-spiroketal skeleton, which are key structural units found in many natural products and pharmacologically active substances. The strategies are mainly based on metallo-, organo- or Lewis acid-catalyzed cycloaddition or annulation reactions.