# Non-Linear Modeling and Precision Analysis Approach for Implantable Multi-Channel Neural Recording Systems

**Authors:** Jinyan He, Jian Xu, Yueming Wang

PMC · DOI: 10.3390/mi16101176 · Micromachines · 2025-10-17

## TL;DR

This paper introduces a modeling approach for implantable neural systems to balance signal quality and efficiency.

## Contribution

A Simulink-based non-linear modeling approach is proposed to optimize neural recording system design.

## Key findings

- THD values of -34.32 dB (LNA), -33.73 dB (PGA), and -57.95 dB (ADC) ensure reliable detection accuracy.
- ADC non-linearity has a greater impact on system performance than LNA and PGA non-linearities.

## Abstract

High-precision implantable multi-channel neural recording systems are considered as having a crucial role in the diagnosis and treatment of neurological disorders. However, it is a significant design challenge to achieve an optimal trade-off among linear parameters, signal fidelity, power consumption, and circuit area. To address this challenge, a Simulink-based modeling approach has been proposed to incorporate adjustable non-linear parameters across the front-end circuits and analog-to-digital converter (ADC) stages. The model evaluates non-linearity impacts on system performance through both quantitative spike detection accuracy analysis and a neural decoding paradigm based on Chinese handwriting reconstruction. Simulated results show that total harmonic distortion (THD) can be set to −34.32 dB for the low-noise amplifier (LNA), −33.73 dB for the programmable gain amplifier (PGA), and −57.95 dB for the ADC in order to achieve reliable detection accuracy with minimal design cost. Moreover, ADC non-linearity has a greater influence on system performance than that of the LNA and PGA. The proposed approach offers quantitative and systematic hardware design guidance to balance signal fidelity and resource efficiency for future low-power, high-accuracy neural recording systems.

## Full-text entities

- **Diseases:** neurological disorders (MESH:D009461)

## Full text

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## Figures

12 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12566353/full.md

## References

58 references — full list in the complete paper: https://tomesphere.com/paper/PMC12566353/full.md

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Source: https://tomesphere.com/paper/PMC12566353