# Eremophilane-Type Sesquiterpenoids from Fungus Aspergillus aurantiobrunneus

## TL;DR

Scientists discovered six new sesquiterpenoids from a fungus and found they don't suppress the immune system at tested levels.

## Contribution

The discovery of six new eremophilane-type sesquiterpenoids with unique structural features from Aspergillus aurantiobrunneus.

## Key findings

- Six new eremophilane-type sesquiterpenoids (aurantiophilanes A–F) were isolated from Aspergillus aurantiobrunneus.
- Compounds 1 and 3 are highly oxygenated eremophilane sesquiterpenoids with rare structural features.
- None of the compounds showed significant immunosuppressive activity at concentrations up to 40 µM.

## Abstract

Six previously undescribed sesquiterpenoids, aurantiophilanes A–F (1–6), along with six identified analogues (7–12), were isolated from the fungus Aspergillus aurantiobrunneus. Among these, compounds 1 and 3 were identified as highly oxygenated eremophilane sesquiterpenoids, with compound 1 featuring a rare ketone functional group at C-1. The structures of all compounds were unambiguously elucidated using comprehensive spectroscopic analyses, including HRESIMS, NMR, and UV spectroscopy, supplemented by electronic circular dichroism (ECD) analyses and single-crystal X-ray diffraction. All identified compounds were evaluated for immunosuppressive activity; none showed significant effects at concentrations up to 40 µM.