# Structural Elucidation and Antiviral Activity Evaluation of Novelly Synthesized Guaiazulene Derivatives

## TL;DR

Scientists synthesized new guaiazulene compounds and found some are effective against the H1N1 flu virus.

## Contribution

Novel guaiazulene derivatives were synthesized and shown to have potent antiviral activity against influenza A (H1N1).

## Key findings

- Six compounds showed significant anti-influenza activity with IC50 values ranging from 50.96 µM to 108.20 µM.
- Compound 3a had the lowest IC50 value at 50.96 µM, indicating strong antiviral potential.
- Ribavirin, used as a control, had an IC50 of 130.22 µM, showing the synthesized compounds are more effective.

## Abstract

A series of guaiazulene derivatives were efficiently synthesized by one-step reaction using guaiazulene as the substrate. Their structures were fully characterized by comprehensive spectroscopic methods, and their antiviral activities against influenza A (H1N1) virus were evaluated. Compounds 2b, 2d, 2e, 2f, 3a, and 3b exhibited significant anti-influenza activity, with IC50 values of 89.03 µM, 98.48 µM, 78.38 µM, 108.20 µM, 50.96 µM, and 56.09 µM, respectively. Ribavirin was used as a positive control (IC50 = 130.22 µM).