# The Impact of K-1 Kickboxing Tournament Fights on Growth Hormone, IGF-1, and Insulin Levels: Preliminary Findings from a Pilot Study in Elite Athletes

**Authors:** Łukasz Rydzik, Ismail Ilbak, Serkan Düz, Tadeusz Ambroży, Tomasz Pałka, Marta Kopańska, Marta Niewczas, Anna Kurkiewicz-Piotrowska, Ibrahim Ouergui, Monika Bigosińska, Wojciech Wąsacz

PMC · DOI: 10.3390/jcm14207203 · Journal of Clinical Medicine · 2025-10-13

## TL;DR

This study found that a single K-1 kickboxing fight significantly increases growth hormone and insulin levels in elite athletes, with changes linked to heart rate and exertion.

## Contribution

The study provides preliminary evidence on acute endocrine responses to K-1 kickboxing and identifies correlations with physiological and perceptual metrics.

## Key findings

- Growth hormone and insulin levels increased significantly after a K-1 fight, but IGF-1 did not.
- Higher final heart rate and perceived exertion correlated with larger increases in growth hormone and insulin.
- More experienced athletes showed smaller hormonal changes after the fight.

## Abstract

Background: Evidence on acute endocrine responses to K-1 kickboxing is limited. This pilot study assessed pre-to-post changes in GH, IGF-1 and insulin after a single K-1 bout and explored relationships with training experience (TE), final heart rate (HRFINAL) and perceived exertion (RPE). Methods: Elite male K-1 athletes (n = 10) completed an interclub, referee-supervised three-round bout (3 × 2 min). Venous blood was sampled pre-fight and +2 min. GH, IGF-1 and insulin were assayed (ELISA). Paired t-tests and Pearson’s r quantified changes and associations. Results: GH rose from 1.20 ± 2.05 to 11.27 ± 8.82 ng/mL (p = 0.007; d = 1.85), and insulin from 5.95 ± 1.56 to 12.95 ± 5.95 µU/mL (p = 0.002; d = 1.86); IGF-1 showed no change (200.90 ± 55.89 to 203.00 ± 54.10 ng/mL; p = 0.497). ΔGH and Δinsulin correlated positively with HRFINAL (rp = 0.89 and 0.88, both p < 0.001) and RPE (rp = 0.70 and 0.68; p = 0.024 and 0.031), and negatively with TE (rp = −0.72 and −0.68; p = 0.019 and 0.031). Conclusions: A single K-1 fight elicited large acute increases in GH and insulin but not IGF-1 at +2 min. HRFINAL and RPE tracked response magnitude, while more experienced athletes showed smaller deltas. Findings are preliminary and limited by a small sample, elite-only cohort, in an interclub setting, with immediate sampling and absence of a control group.

## Linked entities

- **Proteins:** GH1 (growth hormone 1), IGF1 (insulin like growth factor 1), PIN (insulin precursor)

## Full-text entities

- **Genes:** IGF1 (insulin like growth factor 1) [NCBI Gene 3479] {aka IGF, IGF-I, IGFI, MGF}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, GGH (gamma-glutamyl hydrolase) [NCBI Gene 8836] {aka GATD10, GH}, GH1 (growth hormone 1) [NCBI Gene 2688] {aka GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B}
- **Chemicals:** Deltainsulin (-)

## Full text

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## References

60 references — full list in the complete paper: https://tomesphere.com/paper/PMC12565065/full.md

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Source: https://tomesphere.com/paper/PMC12565065