# Pediatric Cardiac Arrest Secondary to Guillain-Barré Syndrome-Induced Dysautonomia

## TL;DR

A child with Guillain-Barré Syndrome rapidly developed life-threatening autonomic dysfunction and cardiac arrest, emphasizing the need for close monitoring and timely treatment.

## Contribution

This case highlights the rare but severe risk of cardiac arrest in pediatric GBS due to dysautonomia, even in initially mild cases.

## Key findings

- Pediatric GBS can rapidly progress to life-threatening dysautonomia and cardiac arrest.
- Early recognition and interventions like plasmapheresis can improve outcomes in non-responders to IVIG.
- Continuous hemodynamic monitoring is essential to prevent fatal outcomes in atypical GBS cases.

## Abstract

What are the main findings?

Pediatric Guillain-Barré Syndrome (GBS) can progress rapidly to life-threatening dysautonomia.

Early cardiac arrest due to autonomic dysfunction may occur even in initially mild cases.

What is the implication of the main finding?

Vigilant monitoring for autonomic instability is critical in pediatric GBS.

Early recognition and timely intervention can improve outcomes.

Background: Guillain-Barré syndrome (GBS) is an acute immune-mediated polyneuropathy often associated with autonomic dysfunction. Although transient cardiovascular instability is common, severe dysautonomia leading to cardiac arrest is rarely documented in children. Methods: We report the case of an 11-year-old previously healthy boy who initially presented with acute ophthalmoplegia and rapidly progressed to quadriplegia and areflexia. He developed fluctuating blood pressure and bradycardia, culminating in cardiac arrest due to asystole at 24 h after admission, requiring 17 min of resuscitation. Results: Electrophysiological studies confirmed a demyelinating polyneuropathy. Although intravenous immunoglobulin (IVIG) was initiated 5 h after admission, clinical improvement was achieved only after subsequent plasmapheresis on day 20, with the recovery of autonomic function by day 35. He was extubated on day 45 and discharged on day 83 with a near-complete recovery after prolonged intensive care and rehabilitation. Conclusion: This case highlights the potential for rapid and life-threatening autonomic instability in pediatric GBS. Unlike typical cases, the patient progressed to cardiac arrest within 24 h despite IVIG, highlighting the need to consider plasmapheresis for non-responders. Continuous hemodynamic monitoring is essential to prevent fatal outcomes, even in patients with initially mild or atypical presentations.