# Biocomposite-Based Biomimetic Plate for Alternative Fixation of Proximal Humerus Fractures

## TL;DR

This study introduces biocomposite plates made from PLA and PVA reinforced with hydroxyapatite for fixing proximal humerus fractures, offering a sustainable and biodegradable alternative to metal implants.

## Contribution

The novel use of hydroxyapatite from sugar industry by-products in biocomposite plates for orthopedic fixation is presented.

## Key findings

- PLA/BCF and PVA/BCF composites showed enhanced mechanical and osteoconductive properties compared to traditional materials.
- PLA/BCF composites are suitable for both injection molding and 3D printing, enabling patient-specific implants.
- Cell viability assays confirmed the cytocompatibility of the biocomposite plates at specific BCF concentrations.

## Abstract

Proximal humerus fractures are frequent injuries that often require internal fixation. Conventional metallic plates, however, present significant drawbacks such as corrosion, secondary removal surgeries, and adverse reactions in patients with metal hypersensitivity. This study evaluates biocomposite plates fabricated from polylactic acid (PLA) and polyvinyl alcohol (PVA), reinforced with hydroxyapatite (HA) derived from sugar industry by-products (BCF) at 10% and 20% concentrations. These composites are compatible with both injection molding and 3D printing, enabling the design of patient-specific implants. Characterization by SEM, FTIR, XRD, and DSC confirmed that BCF incorporation enhances strength, stiffness, osteoconductivity, and biocompatibility. Mechanical testing showed that PVA/BCF exhibited greater tensile strength and stiffness, suggesting suitability for load-bearing applications, though their water solubility restricts use in humid environments and prevents filament-based 3D printing. PLA/BCF composites demonstrated better processability, favorable mechanical performance, and compatibility with both manufacturing routes. Finite element analysis highlighted the importance of plate–humerus contact in stress distribution and fixation stability. Compared with non-biodegradable thermoplastics such as PEI and PEEK, PLA/BCF and PVA/BCF offer the additional advantage of controlled biodegradation, reducing the need for secondary surgeries. Cell viability assays confirmed cytocompatibility, with optimal outcomes at 10% BCF in PVA and 20% in PLA. These results position PLA/BCF and PVA/BCF as sustainable, patient-tailored alternatives to metallic implants, combining adequate mechanical support with bone regeneration potential.