# Role of MRI-Based Radiomics in Sinonasal Cancer Management: A Scoping Review

## TL;DR

This review explores how MRI-based radiomics can help manage sinonasal cancer by identifying aggressive cases or those at higher risk of recurrence.

## Contribution

The paper provides a scoping review of recent studies on radiomics applications in sinonasal cancer management.

## Key findings

- Radiomics is used to predict Ki-67 expression and assess recurrence risk in sinonasal cancer.
- Current studies focus on evaluating response to induction chemotherapy using radiomics.
- Five articles involving 629 patients were analyzed to assess radiomics' potential in this field.

## Abstract

Radiomics could improve the management of sinonasal cancer. In this paper, the potential applications of radiomics in the management of sinonasal cancer have been evaluated, with a particular focus on its role in the early identification of patients with more aggressive disease or at increased risk of recurrence. Whilst the results are encouraging, further validation is required before its adoption in clinical practice.

Background/Objectives: Malignant tumors of the sinonasal tract are rare, accounting for approximately 3–5% of all head and neck tumors. Despite recent advances in therapy, overall survival in sinonasal cancer remains limited, with local recurrence representing the leading cause of treatment failure. Consequently, the preoperative identification of patients at higher risk of recurrence or developing more aggressive tumors is of critical importance to guide treatment strategies and improve outcomes. The aim of this review is to analyze the results of the most recent literature studying the use of radiomics in malignant sinonasal tumors. Methods: A comprehensive literature review was conducted using the PubMed/MEDLINE, EMBASE and Cochrane Library databases, in accordance with the PRISMA review criteria (from 2020 to July 2025). Results: The final analysis comprised a total of five articles and 629 patients. At present, radiomics in sinonasal cancer is mainly applied to the prediction of Ki-67 expression, the early assessment of recurrence risk, and the evaluation of response to induction chemotherapy. Conclusions: The results of this review indicate that radiomics has the potential to play an important role in the management of sinonasal malignant tumors. However, further research is necessary to confirm these findings.