# Multiple Organ Phenotype of Fatigue

## TL;DR

This paper explores how fatigue affects multiple organs and systems, aiming to improve understanding and treatment of fatigue-related conditions.

## Contribution

The paper introduces a new classification of fatigue and explores its physiological connections across multiple systems.

## Key findings

- Fatigue is categorized into sports, occupational, and pathological types based on causes.
- The paper identifies specific manifestations and mechanisms of fatigue in various organ systems.
- Findings suggest potential gene-assisted therapy targets for fatigue-related complications.

## Abstract

Fatigue is not only a widespread subjective experience but also a complex physiological and pathological state involving multiple organs and systems. Currently, there is no consensus on the definition and classification of fatigue. Based on its causes, this paper categorizes fatigue into sports fatigue, occupational fatigue, and pathological fatigue. It elaborates on the specific manifestations and underlying mechanisms of fatigue in the motor, nervous, cardiovascular, digestive, urinary, endocrine, and reproductive systems, aiming to uncover the intrinsic connections of fatigue phenotypes across different systems. These findings may provide key targets for gene-assisted therapy of fatigue-related complications, thereby establishing a new theoretical foundation for the clinical management of fatigue and related research.