Trandolapril Attenuates Pro-Arrhythmic Downregulation of Cx43 and Cx40 in Atria of Volume Overloaded Hypertensive and Normotensive Rats
Matúš Sýkora, Katarína Ondreják Andelová, Alexandra Mrvová, Barbara Szeiffová Bačová, Narcis Tribulová
TL;DR
Trandolapril helps prevent harmful changes in heart proteins in both healthy and hypertensive rats under volume overload.
Contribution
Trandolapril was shown to attenuate pro-arrhythmic downregulation of Cx43 and Cx40 in atria under volume overload.
Findings
Volume overload reduced Cx43 and Cx40 in both atria of normotensive and hypertensive rats.
Trandolapril increased Cx43 and Cx40 levels in atria of volume overloaded rats.
Right heart atria were more susceptible to volume overload effects than left atria.
Abstract
Pressure overload in non-treated or resistant hypertension (HTN) increases the risk of heart failure (HF) as well as the occurrence of fatal ventricular arrhythmias and stroke-provoking atrial fibrillation (AF), while perturbed connexin-43 (Cx43) and Cx40 might be involved. In addition, kidney dysfunction may facilitate hemodynamic volume overload and congestive HF. We investigated the impact of volume overload on Cx43 and Cx40 in right and left heart atria of hypertensive pressure overloaded Ren-2 transgenic (TGR) strain and normotensive Hannover Sprague Dawley (HSD) rats, as well as the efficacy of renin–angiotensin blockade with trandolapril and losartan. Key novel findings revealed lower levels of Cx43 and Cx40 proteins in left as well as right heart atria in pressure overloaded hypertensive rats compared to normotensive rats. There was a significant decrease in Cx43 and Cx40…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsReceptor Mechanisms and Signaling · Cardiac electrophysiology and arrhythmias · Computational Drug Discovery Methods