Ultrastructural and Immunohistochemical Study on the Nephrotoxicity Following Intravitreal Administration of the Antifungal Agents Voriconazole and Micafungin in New Zealand White Rabbits
Sofia Karachrysafi, Vasileios-Alexandros Karakousis, Alexandros Liatsos, Dimitrios Kavvadas, Despoina Ioannou, Pinelopi Anastasiadou, Evangelia Kofidou, Vasileios Karampatakis, Antonia Sioga, Nikolaos Raikos, Theodora Papamitsou
TL;DR
This study investigates kidney damage in rabbits after eye injections of antifungal drugs voriconazole and micafungin.
Contribution
The study reveals potential nephrotoxic effects of intravitreal antifungal agents in rabbits, suggesting clinical relevance for humans.
Findings
Ultrastructural kidney damage was observed, especially in proximal tubules.
Increased expression of EGFR and IL-6 markers was found with drug administration.
Findings suggest a need to study reversibility and adjust dosing to prevent kidney toxicity.
Abstract
The aim of the present study is to examine the possibility of nephrotoxicity following the intravitreal injection of the antifungal agents voriconazole and micafungin. Μale and female New Zealand white rabbits were divided into the control group C that received no medication and the study groups that underwent either one or two intravitreal injections of voriconazole or micafungin solution, respectively, or one co-administration of the two agents. Euthanasia was performed ten days after the last intravitreal administration, and kidney tissue samples were obtained and prepared for electron microscopy study, as well as immunohistochemical study for EGFR and IL-6 markers. Ultrastructural alterations of the renal tissue were found in places of limited extent, more evident at the level of the proximal tubules. The expression of the two markers was positive, especially in the double and the…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25
Figure 26
Figure 27
Figure 28Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsNanoplatforms for cancer theranostics · Ocular Infections and Treatments · Photodynamic Therapy Research Studies