Cytotoxicity of Mimusops caffra-Based Ursolic Acid, Oleanolic Acid and Derivatives Against Human Cancerous and Non-Cancerous Cell Lines
Sithenkosi Mlala, Opeoluwa Oyehan Oyedeji, Gbemisola Morounke Saibu, Mavuto Gondwe, Adebola Omowunmi Oyedeji
TL;DR
This study explores the cancer-fighting potential of compounds derived from the Mimusops caffra plant, showing some derivatives are effective against cancer cells with minimal harm to healthy cells.
Contribution
The study introduces new triterpenoid derivatives of ursolic acid from Mimusops caffra and evaluates their selective cytotoxicity against cancer cells.
Findings
UM (ursolic-28-methylate) showed strong cytotoxicity against cancer cells with minimal impact on non-cancerous cells.
Methyl addition at C-28 of ursolic acid enhances its anti-cancer activity.
Ursolic acid derivatives are potential therapeutic agents for breast, liver, and prostate cancers.
Abstract
According to the World Health Organization, cancer is still the leading cause of death for humans worldwide. Although over 100 chemotherapeutic agents are currently available for the treatment of cancer patients, the overall long term clinical benefit is disappointing due to the lack of effectiveness or severe side effects from these drugs. The use of complementary and alternative medicinal products from plants has continued to increase in past decades, due to fewer side effects of bioactive compounds from medicinal plants of which pentacyclic triterpenoids have been identified as one class of secondary metabolites that could play an important role in the treatment and management of a number of non-communicable diseases. The main aim of this study is to extract, isolate, identify, and elucidate pentacyclic triterpenoid (ursolic acid, UA (1), and oleanolic acid, OA (2)) from Mimusops…
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Taxonomy
TopicsNatural product bioactivities and synthesis · Natural Antidiabetic Agents Studies · Morinda citrifolia extract uses