# Comparison of Different Progesterone Protocols for Luteal Support in Frozen-Thawed Embryo Transfer Preparation

## TL;DR

This study compares different progesterone protocols for luteal support in frozen embryo transfers and finds that combined vaginal and injectable progesterone improves pregnancy and live birth rates.

## Contribution

The study identifies combined vaginal and injectable progesterone as superior to monotherapy for luteal support in frozen embryo transfers.

## Key findings

- Groups using combined vaginal and injectable progesterone had significantly higher serum progesterone levels.
- Clinical pregnancy and live birth rates were higher in combined therapy groups compared to monotherapy.
- Early pregnancy loss was lower in the combined therapy groups.

## Abstract

Objective: To evaluate five luteal support protocols in women with low serum progesterone (<10 ng/mL) undergoing HRT-FET. Methods: Randomized controlled trial at two centers including 200 women under 35 with unexplained infertility. Groups: (1) 600 mg vaginal, (2) 800 mg vaginal, (3) 600 mg vaginal + 50 mg IM, (4) 600 mg vaginal + 25 mg SC, (5) 600 mg vaginal + 30 mg oral. Results: Groups 3 and 4 achieved significantly higher serum progesterone (p < 0.001), higher clinical pregnancy (70%, 68%), and higher live birth (84%, 83%) compared to Groups 1, 2, and 5. Early pregnancy loss was lower in Groups 3 and 4. Conclusions: Combined vaginal and injectable progesterone improved outcomes compared to monotherapy.