# Effects of using auto flow factor function on hemodialysis efficacy in regular hemodialysis patients

**Authors:** Said S. A. Khamis, Ahmed Ragheeb Tawfeek, Mohammed Fathy Ragab, Heba Kamal Abd elkhalk

PMC · DOI: 10.1186/s12882-025-04508-2 · BMC Nephrology · 2025-10-27

## TL;DR

This study found that adjusting dialysate flow automatically during hemodialysis does not affect treatment effectiveness compared to a fixed flow rate.

## Contribution

The study evaluates the impact of an automatic dialysate flow adjustment on hemodialysis efficacy in regular patients.

## Key findings

- Auto Flow Factor Function did not significantly affect dialysis efficacy compared to a fixed flow rate.
- Using Auto Flow may save dialysate and energy without compromising patient outcomes.

## Abstract

Recent HD systems have moved from pre-defined dialysate flow rates (e.g. 300, 500, 800 mL/min) to an individual setting, or an automatic adjustment with a fixed factor of the dialysate flow to the blood flow. Both allows more flexibility of choosing the appropriate dialysate flow as an optimal adjustment to the current blood flow.

To study the possible effects of using autoflow factor function on hemodialysis (HD) efficacy in regular hemodialysis patients.

A prospective cross section study included 55 ESRD patients on hemodialysis and conducted in hemodialysis unit in Menoufia university hospital.

There was no statistically significant difference between the dialysate flow rate 500 mL/min and auto Flow factor regarding the Kt/V (p = 0.068).

The present study demonstrates that the use of the Auto Flow Factor Function does not result in a statistically significant difference in dialysis efficacy compared to a fixed dialysate flow rate of 500 mL/min. Given the potential for dialysate and energy savings, the implementation of Auto Flow may represent a step toward environmentally sustainable dialysis without compromising patient care.

## Linked entities

- **Diseases:** end-stage renal disease (MONDO:0004375)

## Full-text entities

- **Diseases:** ESRD (MESH:D007676)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12560424/full.md

## References

3 references — full list in the complete paper: https://tomesphere.com/paper/PMC12560424/full.md

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Source: https://tomesphere.com/paper/PMC12560424