# Cannabizetol, a Novel Cannabinoid: Chemical Synthesis, Anti-inflammatory Activity and Extraction from Cannabis sativa L

## TL;DR

Scientists discovered a new cannabinoid in cannabis with strong anti-inflammatory properties, which could be useful for skin treatments.

## Contribution

The first isolation and synthesis of cannabizetol, a novel dimeric cannabinoid with high anti-inflammatory activity.

## Key findings

- Cannabizetol was isolated from Cannabis sativa and chemically synthesized for identification.
- It shows higher antioxidant and anti-inflammatory activity than cannabitwinol.
- A continuous flow method was developed to efficiently prepare these dimeric cannabinoids.

## Abstract

We report the first isolation of
a previously unknown cannabinoid,
cannabizetol (CBGD, 7), from Cannabis sativa extracts, representing the third member of the rare class of methylene-bridged
dimeric cannabinoids. The availability of a chemically synthesized
standard was crucial for its unequivocal identification, thus confirming
the natural occurrence of this new compound. In addition to this structural
discovery, we demonstrate that cannabizetol exhibits remarkable antioxidant
and skin anti-inflammatory activity, significantly higher than that
observed for the known dimeric cannabinoid cannabitwinol (CBDD, 6). These results highlight cannabizetol as a promising bioactive
metabolite with potential dermatological applications. To further
enable its study, we developed a continuous flow approach to optimize
the preparation of these dimers, achieving a substantial reduction
in reaction times.