# Neuroregenerative Treatment With Radio Electric Asymmetric Conveyer Technology in Advanced Childhood Cerebral X-linked Adrenoleukodystrophy: Clinical Stabilization and Electroencephalographic Evidence of Cortico-Subcortical Reorganization

## TL;DR

A child with advanced cerebral X-linked adrenoleukodystrophy showed clinical improvement and brain activity changes after a novel neuroregenerative treatment.

## Contribution

This case study presents clinical stabilization and neurophysiological evidence of brain reorganization following REAC RGN-N treatment in advanced X-linked adrenoleukodystrophy.

## Key findings

- Post-treatment EEG showed improved background activity and reduced epileptiform discharges.
- Clinical improvements included decreased spasticity, visual tracking recovery, and reduced hospitalization needs.
- Objective evidence of cortico-subcortical reorganization was observed despite the expected disease progression.

## Abstract

We describe the case of a male child with advanced childhood cerebral X-linked adrenoleukodystrophy (Loes score 15) who underwent five cycles of radio electric asymmetric conveyer (REAC) neuro regenerative (RGN-N) treatment over a two-year period. Clinical assessments and neurophysiological recordings were performed at baseline and during follow-up. The pre-treatment electroencephalogram (EEG) and brain mapping showed disorganized background activity for age, continuous bilateral frontal slowing, and abundant epileptiform discharges with right-sided predominance. Post-treatment evaluations performed four months after the last cycle revealed background activity appropriate for age, a reduction of slowing to intermittent focal changes confined to the left frontal region, and a restriction of epileptiform activity to a small area involving the right centro-rolandic region. Sustained clinical stabilization was observed, with decreased spasticity (Modified Ashworth Scale from 3 to 1), recovery of visual tracking, improved emotional responsiveness, and resolution of the conditions that had previously required repeated hospitalizations, along with discontinuation of oxygen therapy and airway suctioning. These findings contrast with the expected course of progressive deterioration in this condition and provide objective neurophysiological evidence of cortical reorganization associated with REAC RGN-N treatment. Further studies are warranted to explore the potential of this therapeutic approach in advanced stages of neurodegenerative disorders.