# Thymectomy for Morvan Syndrome Associated With Thymoma

**Authors:** Daichi Kakibuchi, Shunta Ishihara, Masanori Shimomura, Satoru Okada, Tatsuo Furuya, Masayoshi Inoue

PMC · DOI: 10.1016/j.atssr.2025.03.016 · Annals of Thoracic Surgery Short Reports · 2025-04-03

## TL;DR

A 67-year-old man with Morvan syndrome and a thymoma showed improved symptoms after surgery and immunosuppressive therapy.

## Contribution

This case demonstrates the effectiveness of combining thymectomy with immunosuppressive therapy for Morvan syndrome.

## Key findings

- The patient's neurological symptoms improved after robotic subxiphoid-optical extended thymectomy.
- Combining surgery with immunosuppressive therapy may benefit Morvan syndrome associated with thymoma.

## Abstract

A 67-year-old man presented with lower back pain, numbness in the lower limbs, and general malaise. Over time, he experienced insomnia, abnormal behavior, muscle weakness, weight loss, orthostatic hypotension, and vesicorectal dysfunction. He was given a diagnosis of Morvan syndrome. Chest computed tomography revealed a 4.5-cm mass in the anterior mediastinum. He underwent steroid pulse therapy and therapeutic plasmapheresis, followed by robotic subxiphoid-optical extended thymectomy. His neurologic symptoms improved, and he was discharged 3 months after surgery. This case highlights the potential benefits of combining surgery with immunosuppressive therapy for managing Morvan syndrome and improving neurologic symptoms associated with thymoma.

## Linked entities

- **Diseases:** Morvan syndrome (MONDO:0008718), thymoma (MONDO:0006456)

## Full-text entities

- **Diseases:** muscle weakness (MESH:D018908), back pain (MESH:D001416), vesicorectal dysfunction (MESH:D006331), Thymoma (MESH:D013945), insomnia (MESH:D007319), weight loss (MESH:D015431), numbness (MESH:D006987), Morvan Syndrome (OMIM:201300), orthostatic hypotension (MESH:D007024)
- **Chemicals:** steroid (MESH:D013256)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12559609/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12559609/full.md

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Source: https://tomesphere.com/paper/PMC12559609