# Benchmarking large language models for personalized, biomarker-based health intervention recommendations

## TL;DR

This paper benchmarks large language models for personalized health recommendations based on biomarkers and finds that proprietary models perform better but still have limitations.

## Contribution

The study introduces an open-source framework for benchmarking LLMs in personalized longevity interventions with clinician-validated test cases.

## Key findings

- Proprietary models outperformed open-source models in comprehensiveness of recommendations.
- LLMs struggled with medical validation requirements and age-related biases even with RAG.
- The framework provides a foundation for future AI benchmarking in medical contexts.

## Abstract

The use of large language models (LLMs) in clinical diagnostics and intervention planning is expanding, yet their utility for personalized recommendations for longevity interventions remains opaque. We extended the BioChatter framework to benchmark LLMs’ ability to generate personalized longevity intervention recommendations based on biomarker profiles while adhering to key medical validation requirements. Using 25 individual profiles across three different age groups, we generated 1000 diverse test cases covering interventions such as caloric restriction, fasting and supplements. Evaluating 56000 model responses via an LLM-as-a-Judge system with clinician validated ground truths, we found that proprietary models outperformed open-source models especially in comprehensiveness. However, even with Retrieval-Augmented Generation (RAG), all models exhibited limitations in addressing key medical validation requirements, prompt stability, and handling age-related biases. Our findings highlight limited suitability of LLMs for unsupervised longevity intervention recommendations. Our open-source framework offers a foundation for advancing AI benchmarking in various medical contexts.