Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet
Zeinab Gawish, Maha Gamal, Dalia Azmy Elberry, Esraa A. Hegazy, Laila Ahmed Rashed, Sara Adel Hosny, Marwa Nagi Mehesen, Asmaa Mohammed ShamsEldeen
TL;DR
A high-fat diet in rats leads to early amyloid buildup in gut nerves and memory issues before brain damage occurs.
Contribution
Shows early amyloid-β accumulation in the gut nervous system precedes brain involvement with high-fat diets.
Findings
High-fat diet caused memory deficits and amyloid-β in gut nerves after 4-8 weeks.
Amyloid-β deposition in the myenteric plexus occurred before cerebral cortex involvement.
Longer high-fat diet duration worsened spatial memory and gut mucosa damage.
Abstract
Consumption of a high-fat diet (HFD) contributes to numerous chronic illnesses, including neurological disorders and gastrointestinal dysfunction. The study design included four groups, each consisting of six rats: the control group was fed regular chow, while groups 2 (HFD 2W), 3 (HFD 4W), and 4 (HFD 8W) were given a 60% HFD for 2, 4, and 8 weeks, respectively. A significant change in the latency to the platform in the water maze, a decrease in the percentage of successful cycles in the Y-maze, and a reduction in the percentage of time spent with the novel object were observed between the baseline and endpoint results in the HFD 4W and HFD 8W groups; notably, this was not the case in the control and HFD 2W groups. Consistent with the increased duration of HFD intake, marked damage to the cortical pyramidal cells as well as the mucosa of the ileum and colon was recorded. The optical…
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Taxonomy
TopicsDiet and metabolism studies · Gut microbiota and health · Biochemical effects in animals