Development and characterisation of fast dispersible dimenhydrinate tablets: Compactional study and in-silico PBPK modeling
Uroosa Maqbool, Farya Zafar, Riffat Yasmin, Huma Ali, Hira Akhtar, Rizwana Rehmat, Yumna Tahir, Iqra Haider, Shumaila Anwar, Javeria Ameer
TL;DR
This study developed fast dispersible dimenhydrinate tablets using a cost-effective method and validated their performance with modeling.
Contribution
A novel compactional study and in-silico PBPK modeling approach for optimizing fast dispersible dimenhydrinate tablets.
Findings
Formulation F2 showed optimal mechanical strength and complete drug release within 15 minutes.
In-silico modeling predicted pharmacokinetic parameters comparable to experimental values.
All formulations were stable under accelerated conditions and followed the Weibull dissolution model.
Abstract
The aim of this study was to optimize and evaluate dimenhydrinate fast dispersible tablets (50 mg) by utilizing cost effective direct compression method. A total of nine formulations (F1-F9) were designed and developed by central composite rotatable design using design expert® software (version 11.0, Stat-Ease Inc.,) to study the impact of avicel PH102 (15–55%) and sodium starch glycolate (2–8%) on responses, i.e., hardness (R1), disintegration time (R2) and % drug release (R3). Powder blends of all formulations showed good flow behavior. Post compressional studies were conducted to assess the quality attributes of the compressed formulations. Formulation F2 was found to be optimized with good mechanical strength, i.e., hardness 4.2 kg, friability 0.77%, disintegration time 19 secs and % drug release 100.01% at 15 minutes. Compressional behavior of optimized formulation was determined…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25
Figure 26
Figure 27
Figure 28
Figure 29
Figure 30
Figure 31
Figure 32
Figure 33
Figure 34
Figure 35
Figure 36
Figure 37
Figure 38
Figure 39
Figure 40
Figure 41
Figure 42
Figure 43
Figure 44
Figure 45
Figure 46Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsDrug Solubulity and Delivery Systems · Crystallization and Solubility Studies · Advanced Drug Delivery Systems