# Ruptured Gastrointestinal Stromal Tumor in a 12-Year-Old Child: A Case Report

**Authors:** Ashwin Rajkumar J, Prakash Agarwal, Madhu R, Jegadeesh Sundaram, Latha M Sneha

PMC · DOI: 10.7759/cureus.93353 · 2025-09-27

## TL;DR

A 12-year-old girl with a rare ruptured stomach tumor was treated with medicine and surgery, highlighting the need for early action and personalized care in children with this condition.

## Contribution

This case report adds to the limited literature on pediatric GISTs, emphasizing treatment strategies and outcomes in children.

## Key findings

- The patient had a large gastric GIST that ruptured, leading to internal bleeding.
- Histopathology confirmed an epithelioid-type GIST, and treatment with imatinib was continued.
- Pediatric GISTs have better survival outcomes than adult cases, but require multidisciplinary care.

## Abstract

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms, especially in pediatric patients, often presenting with distinct clinical and molecular characteristics. This case report describes a 12-year-old girl with a large gastric GIST complicated by tumor rupture and hemoperitoneum. Initial treatment with imatinib was followed by emergent surgical intervention due to tumor bleeding. Histopathology confirmed an epithelioid-type GIST, necessitating continued imatinib therapy. Pediatric GISTs demonstrate an indolent but unpredictable course, requiring a multidisciplinary approach. Despite their aggressive nature, pediatric cases show better survival outcomes than adults. This case underscores the importance of timely intervention, individualized therapy, and long-term follow-up to improve prognosis in children with GISTs.

## Linked entities

- **Chemicals:** imatinib (PubChem CID 5291)
- **Diseases:** gastrointestinal stromal tumors (MONDO:0011719)

## Full-text entities

- **Diseases:** mesenchymal neoplasms (MESH:D009369), bleeding (MESH:D006470), GIST (MESH:D046152), tumor rupture (MESH:D012421), hemoperitoneum (MESH:D006465)
- **Chemicals:** imatinib (MESH:D000068877)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12558428/full.md

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Source: https://tomesphere.com/paper/PMC12558428