# Comparing quality of life after robot assisted versus open radical cystectomy: A systematic review

## TL;DR

This paper compares quality of life outcomes after two types of bladder cancer surgery and finds no significant difference between them.

## Contribution

The study systematically reviews and compares HRQoL outcomes following robot-assisted versus open radical cystectomy.

## Key findings

- No statistically significant differences in HRQoL were found between robot-assisted and open radical cystectomy.
- There is a lack of standardized PROMs and limited functional assessment in current studies.
- Heterogeneity and inconsistent reporting limit the comparability of results.

## Abstract

Bladder cancer is a common malignancy in both sexes. Robot-assisted approaches are increasingly used in its surgical management. Radical cystectomy can significantly affect health-related quality of life (HRQoL), typically assessed using patient-reported outcome measures (PROMs) that capture patients’ physical, psychological, and social well-being.

To systematically compare HRQoL and functional outcomes following robot-assisted versus open radical cystectomy (RARC vs. ORC) for bladder cancer, and to evaluate the methodologies employed, including PROMs and postoperative assessment timepoints.

A systematic search of CENTRAL, Embase, PubMed, and Scopus (2000–2025) was performed for randomised and non-randomised studies comparing HRQoL outcomes after RARC and ORC. Eligible studies reporting PROM-based HRQoL were included. Data were extracted on patient characteristics, PROMs, and outcome domains, and synthesised descriptively.

Nine studies involving 1,575 patients met inclusion criteria. Seven HRQoL domains were identified, assessed using 18 PROMs; the EORTC QLQ-C30 was most frequently applied (n = 4). HRQoL was typically assessed at 3, 6, and 12 months, with only one study extending beyond 12 months. Functional assessment was limited: one study employed the Internation Index of Erectile Function (IIEF-5) for male erectile function, none assessed female sexual function, and one reported objective continence outcomes. Across studies, no statistically significant differences in HRQoL were observed between RARC and ORC. However, heterogeneity in PROMs, inconsistent outcome reporting, and high risk of bias limited comparability.

Current evidence does not demonstrate a HRQoL advantage of RARC over ORC. Standardisation of PROMs, consistent follow-up intervals, and inclusion of functional domains are essential to strengthen comparative evidence and inform the role of RARC as a potential new standard of care.

The online version contains supplementary material available at 10.1007/s11701-025-02902-4.