# Ameloblastic Fibrosarcoma Transformation From Recurrent Ameloblastic Fibroma: A Case Report From Morocco

**Authors:** Sanae Soudani, Fatima Safini, Kenza Oqbani, Sanae Abbaoui, Bouchra Amaoui

PMC · DOI: 10.7759/cureus.93274 · 2025-09-26

## TL;DR

A rare case of ameloblastic fibrosarcoma in a Moroccan patient developed from a pre-existing benign tumor and led to lung metastasis.

## Contribution

This case report highlights the transformation of a benign tumor into a malignant one with metastasis, emphasizing diagnostic and management challenges.

## Key findings

- Ameloblastic fibrosarcoma can arise from a pre-existing ameloblastic fibroma.
- The case involved lung metastasis, underscoring the aggressive nature of the tumor.
- Accurate diagnosis and total surgical excision are critical for management.

## Abstract

Ameloblastic fibrosarcoma is an extremely rare odontogenic sarcoma, which consists of a benign epithelial and a malignant mesenchymal component. This rare tumor occurs de novo or from a pre-existing ameloblastic fibroma. We report a case of a 31-year-old male patient who developed a lung metastasis fibrosarcoma secondary to ameloblastic fibrosarcoma arising on a pre-existing mandibular ameloblastic fibroma. A thorough understanding of the radiological and histological aspects of mandibular tumors is essential to establish an accurate diagnosis and rule out other common benign and malignant odontogenic tumors that might display microscopic similarities. An appropriate management, including total surgical excision with safe margins, represents the preferred treatment of ameloblastic fibroma. Close monitoring is indicated to reduce the recurrence rate.

## Full-text entities

- **Diseases:** Ameloblastic Fibrosarcoma (MESH:D005354), odontogenic tumors (MESH:D009808), tumor (MESH:D009369), Ameloblastic Fibroma (MESH:D005350), odontogenic sarcoma (MESH:D018126), lung metastasis (MESH:D009362), mandibular tumors (MESH:D008339)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12554256/full.md

---
Source: https://tomesphere.com/paper/PMC12554256