# Malignant Mucosal Melanoma of the Paranasal Sinuses

**Authors:** Naglaa Elsayed, Aseil Mahboob, Aisha Almassawi

PMC · DOI: 10.7759/cureus.93257 · 2025-09-26

## TL;DR

This paper reports a case of rare sinonasal melanoma in a 74-year-old man who died shortly after surgery.

## Contribution

The study presents a clinical case of malignant mucosal melanoma in the paranasal sinuses with a fatal outcome.

## Key findings

- The patient presented with nasal obstruction and epistaxis, initially misdiagnosed as fungal sinusitis.
- MRI confirmed an aggressive mass, and biopsy confirmed sinonasal melanoma.
- The patient died one week after surgical resection of the tumor.

## Abstract

Sinonasal melanoma is a rare malignant tumor arising from the melanocytes of the paranasal sinuses. It has local and distant metastasis. This study reports a case of sinonasal melanoma at King Abdullah Medical Center. A 74-year-old male patient presented with unilateral nasal obstruction and epistaxis. A contrast-enhanced CT scan of the brain and paranasal sinuses showed findings suggestive of invasive fungal sinusitis. Following this finding, the patient was referred for an MRI scan, which confirmed the aggressive nature of the mass. Subsequently, a biopsy was taken from the mass, which proved sinonasal melanoma. The patient underwent surgical resection of the lesion. Histopathology confirmed the diagnosis of sinonasal melanoma. Unfortunately, the patient passed away one week after the operation.

## Full-text entities

- **Diseases:** nasal obstruction (MESH:D015508), Mucosal Melanoma (MESH:D008545), Malignant (MESH:D009369), epistaxis (MESH:D004844), fungal sinusitis (MESH:D000092562), metastasis (MESH:D009362)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

10 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12554011/full.md

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Source: https://tomesphere.com/paper/PMC12554011