Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
Melih Oztepe, Demet Coskun, Ferda Ari
TL;DR
A new chalcone derivative shows selective anticancer effects on colon cancer cells by inducing apoptosis and cell cycle arrest.
Contribution
A novel benzofuran-linked 3-nitrophenyl chalcone derivative was synthesized and shown to selectively target colon cancer cells.
Findings
The compound exhibited selective cytotoxicity with IC₅₀ values of 1.71 µM for HCT-116 and 7.76 µM for HT-29 cells.
It induced apoptosis via DR-4 and BCL-2 pathways and arrested the cell cycle at the G0/G1 phase.
The derivative inhibited cell migration and colony formation in a dose-dependent manner.
Abstract
Cancer is the second biggest cause of death after cardiovascular disorders and its incidence is rising significantly. One out of every ten cancer-related deaths is caused by colon cancer. The increasing incidence calls for creating focused therapeutic strategies with fewer adverse effects than traditional clinical techniques like radiation, chemotherapy, and immunotherapy. In this study, we evaluated the anticancer effects and mechanisms of a synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative, [1-(2-benzofuranyl)-3-(3-nitrophenyl)-2-propen-1-one], on colon cancer cells (HCT-116 and HT-29) as well as healthy colon cells (CCD-18Co). Cell viability analyses using the sulforhodamine B assay demonstrated that the IC₅₀ values after 48 h of treatment were 1.71 µM for HCT-116, 7.76 µM for HT-29, and higher than 10 µM for CCD-18Co cells. These results indicate…
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Taxonomy
TopicsSynthesis and biological activity · Genomics, phytochemicals, and oxidative stress · Synthesis and Characterization of Heterocyclic Compounds