# Progressive scattered and reticular pigmentation lesions

**Authors:** Yao Zhou, Lining Huang, Chao Yang, Zhijun Xu, Amira Elbendary, Ruzeng Xue

PMC · DOI: 10.1016/j.jdcr.2025.08.016 · 2025-08-29

## Full-text entities

- **Genes:** PSENEN (presenilin enhancer, gamma-secretase subunit) [NCBI Gene 55851] {aka ACNINV2, MDS033, MSTP064, PEN-2, PEN2}, KRT5 (keratin 5) [NCBI Gene 3852] {aka CK5, DDD, DDD1, EBS1, EBS2, EBS2A}, NF1 (neurofibromin 1) [NCBI Gene 4763] {aka NFNS, VRNF, WSS}, POFUT1 (protein O-fucosyltransferase 1) [NCBI Gene 23509] {aka DDD2, FUT12, O-FUT, O-Fuc-T, O-FucT-1, OFUCT1}, ADAM10 (ADAM metallopeptidase domain 10) [NCBI Gene 102] {aka AD10, AD18, CD156c, CDw156, HsT18717, MADM}, POGLUT1 (protein O-glucosyltransferase 1) [NCBI Gene 56983] {aka C3orf9, CLP46, KDELCL1, KTELC1, LGMD2Z, LGMDR21}, CDH1 (cadherin 1) [NCBI Gene 999] {aka Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM}
- **Diseases:** DDD (MESH:C562924), hyperpigmented macules (MESH:C537836), blister (MESH:D001768), hyperpigmentation (MESH:D017495), Haber syndrome (MESH:D013577), rosacea (MESH:D012393), eczematous dermatitis (MESH:D004485), Intertriginous freckling (MESH:D008548), endocrine disorders (MESH:D004700), malignancy (MESH:D009369), diabetes mellitus (MESH:D003920), insulin resistance (MESH:D007333), atrophy (MESH:D001284), pigmentation disorder (MESH:D010859), obesity (MESH:D009765), papillomatous (MESH:D058066), facial erythema (MESH:D004890), Acanthosis nigricans (MESH:D000052), Pruritus (MESH:D011537)
- **Chemicals:** tretinoin (MESH:D014212), etretinate (MESH:D005050)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** 2-base pair deletion at positions 442

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12552139/full.md

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Source: https://tomesphere.com/paper/PMC12552139