# Infectious Mimics of Bell's Palsy: Facial Nerve Palsy Due to Lyme Neuroborreliosis

**Authors:** Tha Mon, Aye Nyein, Aung Oo

PMC · DOI: 10.7759/cureus.93122 · 2025-09-24

## TL;DR

This paper presents a case where facial nerve palsy was caused by Lyme disease, highlighting the need for thorough evaluation to avoid misdiagnosis.

## Contribution

The paper adds a clinical case emphasizing the importance of considering Lyme neuroborreliosis in facial palsy diagnosis.

## Key findings

- A 47-year-old man with bilateral facial nerve palsy was diagnosed with Lyme neuroborreliosis.
- Treatment with IV ceftriaxone led to significant improvement in facial nerve function.
- Normal MRI findings did not rule out neuroborreliosis, underscoring the need for CSF analysis and serology.

## Abstract

Facial nerve palsy (FNP) is a common neurological disorder. There are multiple causes of FNP, and Bell’s palsy is defined as an idiopathic cause of FNP. If a patient presents with facial palsy, a full investigation workup should be performed. Lyme disease can present with erythema migrans, fever, headache, muscle and joint pain, and facial palsy. We present a case of a 47-year-old man who presented with progression from unilateral to bilateral FNP. After a series of investigations, he was diagnosed with LNB. Even if MRI findings are normal, cerebrospinal fluid (CSF) analysis and Lyme serology (enzyme-linked immunosorbent assay followed by Western blot) in serum and/or CSF can confirm the diagnosis of neuroborreliosis. We have administered the patient IV ceftriaxone 2 g daily, as per the guidelines. He showed gradual improvement in FNP from House-Brackmann Grade V to Grade II on subsequent follow-ups. This case emphasizes the importance of broad clinical evaluation in diagnosing FNP. Early detection of LNB and initiation of treatment can ensure patients have a favorable outcome.

## Linked entities

- **Chemicals:** ceftriaxone (PubChem CID 5479530)
- **Diseases:** Lyme disease (MONDO:0019632), Bell's palsy (MONDO:0005665), facial nerve palsy (MONDO:0005665)

## Full-text entities

- **Diseases:** FNP (MESH:D005155), Bell's Palsy (MESH:D020330), Lyme Neuroborreliosis (MESH:D020852), headache (MESH:D006261), neurological disorder (MESH:D009461), muscle and joint pain (MESH:D063806), fever (MESH:D005334), Lyme (MESH:D008193), facial palsy (MESH:D005158), erythema migrans (MESH:D005929)
- **Chemicals:** ceftriaxone (MESH:D002443)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12551795/full.md

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Source: https://tomesphere.com/paper/PMC12551795