Rare Brain Tumor in Infancy: Intraparenchymal Meningioma with Suspected Meningioangiomatosis in a Nine‑Month‑Old

TL;DR

A rare brain tumor, meningioma, was found in a nine-month-old infant and successfully treated with surgery.

Contribution

This case highlights the atypical presentation of meningiomas in infants and their successful management.

Findings

A nine-month-old had a WHO grade 2 meningioma without dural attachment.

The patient remained seizure-free and recurrence-free after surgery.

Histopathology and methylation profiling confirmed the meningioma diagnosis.

Abstract

An exceptionally rare case is described of intraparenchymal WHO grade 2 meningioma with suspected meningioangiomatosis in a nine‑month‑old boy presenting with absence seizures. MRI revealed a heterogeneously enhancing right frontal mass without dural attachment, encasing MCA branches. Histopathology confirmed atypical meningioma with adjacent perivascular meningothelial proliferation. Methylation profiling supported the diagnosis. Following gross total resection without adjuvant therapy, the patient remains seizure‑free with no recurrence at four‑year follow‑up.

Teaching point: Pediatric meningiomas are rare tumors that exhibit atypical presentations compared to their adult counterparts and should be included in the differential diagnosis of intra‑axial lesions in children.

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