# Benign Cutaneous Neoplasms with Syndromic Associations

## TL;DR

This paper reviews how certain benign skin growths can signal underlying genetic disorders and potential internal cancers.

## Contribution

The paper provides a comprehensive overview of clinical and histologic features linking benign skin neoplasms to syndromic associations.

## Key findings

- Benign skin neoplasms can indicate hereditary syndromes with potential internal malignancies.
- Dermatopathologists can identify syndromic clues through lesion patterns and immunohistochemical testing.
- Recognizing these associations helps guide clinicians toward appropriate genetic testing and screening.

## Abstract

There are many benign skin neoplasms encountered in dermatopathology practice that can be associated with underlying genetic disorders. Although benign themselves, these lesions can offer insight into the potential for development of internal malignancies in patients with these hereditary syndromes. An astute dermatopathologist will recognize clues that suggest a syndromic association of these lesions, such as the presence of multiple lesions, distinct histologic growth patterns, and the results of ancillary immunohistochemical testing. The dermatopathologist can then guide the referring clinician to obtain additional clinical and family history and, if appropriate, pursue further screening and genetic testing. This review article will provide an overview of the clinical and histologic features associated with select common and uncommon benign skin neoplasms with syndromic associations.