# Analysis of breast region segmentation in thermal images using U-Net deep neural network variants

**Authors:** Rafhanah Shazwani Rosli, Mohamed Hadi Habaebi, Md Rafiqul Islam, Mohammed Abdulla Salim Al Hussaini

PMC · DOI: 10.3389/fbinf.2025.1609004 · Frontiers in Bioinformatics · 2025-10-10

## TL;DR

This paper compares different U-Net models for segmenting breast regions in thermal images, finding that a simpler U-Net with the ADAM optimizer performs best for breast cancer detection.

## Contribution

The study demonstrates that a baseline U-Net with ADAM optimizer outperforms more complex variants in breast region segmentation from thermal images.

## Key findings

- U-Net with ADAM optimizer achieved highest precision (0.9721), recall (0.9559), and ROC-AUC (0.9680).
- More complex U-Net variants did not perform better than the baseline model.
- ADAM optimizer consistently outperformed other optimization algorithms in segmentation accuracy.

## Abstract

Breast cancer detection using thermal imaging relies on accurate segmentation of the breast region from adjacent body areas. Reliable segmentation is essential to improve the effectiveness of computer-aided diagnosis systems.

This study evaluated three segmentation models—U-Net, U-Net with Spatial Attention, and U-Net++—using five optimization algorithms (ADAM, NADAM, RMSPROP, SGDM, and ADADELTA). Performance was assessed through k-fold cross-validation with metrics including Intersection over Union (IoU), Dice coefficient, precision, recall, sensitivity, specificity, pixel accuracy, ROC-AUC, PR-AUC, and Grad-CAM heatmaps for qualitative analysis.

The ADAM optimizer consistently outperformed the others, yielding superior accuracy and reduced loss. Among the models, the baseline U-Net, despite being less complex, demonstrated the most effective performance, with precision of 0.9721, recall of 0.9559, specificity of 0.9801, ROC-AUC of 0.9680, and PR-AUC of 0.9472. U-Net also achieved higher robustness in breast region overlap and noise handling compared to its more complex variants. The findings indicate that greater architectural complexity does not necessarily lead to improved outcomes.

This research highlights that the original U-Net, when trained with the ADAM optimizer, remains highly effective for breast region segmentation in thermal images. The insights contribute to guiding the selection of suitable deep learning models and optimizers for medical image analysis, with the potential to enhance the efficiency and accuracy of breast cancer diagnosis using thermal imaging.

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989)

## Full-text entities

- **Diseases:** Breast cancer (MESH:D001943)

## Full text

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## Figures

18 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12550958/full.md

## References

41 references — full list in the complete paper: https://tomesphere.com/paper/PMC12550958/full.md

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Source: https://tomesphere.com/paper/PMC12550958