# Inhibition of acn-1 , an ACE ortholog, reduces intestinal GST-4 expression in Caenorhabditis elegans

## TL;DR

This study shows that inhibiting a worm version of a human enzyme reduces antioxidant production in the worm's intestine.

## Contribution

The novel finding is that acn-1 positively regulates gst-4 expression in C. elegans.

## Key findings

- acn-1 RNAi exposure reduces GST-4 reporter expression in C. elegans.
- The reduction in GST-4 expression is most notable in the intestine.
- acn-1 positively influences gst-4 expression in C. elegans.

## Abstract

We investigated the role of

acn-1

, the

C. elegans

ortholog of human ACE and ACE2, on the expression of
GST-4
, an antioxidant molecule produced in response to oxidative stress.

acn-1

RNAi exposure significantly reduced
GST-4
reporter expression after 24 and 48 hours. The difference in

gst-4

expression appears most prevalent in the intestine. Our findings suggest that

acn-1

function
positively influences

gst-4

expression in

C. elegans

.