# The “sandwich” procedure for paracentral rheumatoid corneal perforation: a case report with 6-year follow-up and literature review

**Authors:** Yi Zhang, Hanjing Liu, Qing Li, Yan Zhu, Yu-guang Zhu

PMC · DOI: 10.3389/fmed.2025.1649417 · Frontiers in Medicine · 2025-10-10

## TL;DR

A new surgical procedure called the 'sandwich' method successfully treated a rare corneal perforation in a patient with rheumatoid arthritis, maintaining vision for six years.

## Contribution

The paper introduces the novel 'sandwich' surgical procedure for treating paracentral rheumatoid corneal perforation.

## Key findings

- The 'sandwich' procedure provided tectonic support and stabilized the corneal perforation.
- The patient maintained 20/50 best-corrected visual acuity over a 6-year follow-up.
- This is the first reported use of the 'sandwich' procedure for this specific condition.

## Abstract

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease often associated with ocular manifestations. In rare cases of RA, paracentral rheumatoid corneal perforation may occur. We report the case of a 53-year-old monocular woman with a 20-year history of RA who presented to the clinic with a paracentral corneal perforation. Slit-lamp examination revealed a 2-mm diameter paracentral perforation with an iris plug. The patient was clinically diagnosed with sterile rheumatoid corneal perforation. We describe an innovative “sandwich” procedure developed for addressing the corneal perforation. Initially, a partial thickness limbal groove was created outside the perforation, followed by the formation of a semicircular intrastromal pocket extending approximately 2 mm inside the perforation edge. A lamellar graft was then fashioned and inserted into the intrastromal pocket. Subsequently, the limbal groove was closed, and a conjunctival flap was used to cover the perforated area. Upon follow-up, the “sandwich” procedure provided sufficient tectonic support for the patient’s only eye, resulting in a stable ocular surface. Over a 6-year follow-up period, the postoperative best-corrected visual acuity (BCVA) was maintained at 20/50. To the best of our knowledge, this is the first report of the “sandwich” procedure for paracentral rheumatoid corneal perforation.

## Linked entities

- **Diseases:** rheumatoid arthritis (MONDO:0008383)

## Full-text entities

- **Diseases:** RA (MESH:D001172), corneal perforation (MESH:D057112), autoimmune disease (MESH:D001327)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12549618/full.md

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Source: https://tomesphere.com/paper/PMC12549618