# The morphological pathogenesis of isolated superior mesenteric artery dissection

## TL;DR

This study explores how anatomical features like artery curvature and tortuosity may contribute to a rare arterial disease called isolated superior mesenteric artery dissection.

## Contribution

The study identifies curvature and tortuosity as independent anatomical predictors of isolated superior mesenteric artery dissection.

## Key findings

- Higher curvature is an independent predictor of ISMAD occurrence.
- Lower tortuosity is significantly associated with ISMAD.
- Anatomical factors may play a role in the pathogenesis of ISMAD.

## Abstract

Isolated superior mesenteric artery dissection (ISMAD) is a rare arterial disease, and its exact cause is still not well understood. This study aimed to investigate the potential role of anatomical factors in the development of ISMAD.

This case-control study included patients diagnosed with ISMAD via computed tomography angiography from two major medical centers in China. An equal number of age-sex and body mass index matched patients without aortic and superior mesenteric artery disease were selected as controls. Several anatomical parameters were compared between the ISMAD group and the control group. Significant parameters were identified through univariate and multivariate analyses, and models were evaluated using receiver operating characteristic (ROC) curve analysis. A p-value < 0.05 was considered statistically significant.

A total of 60 patients with isolated superior mesenteric artery dissection and 60 age-sex (52.6 ± 6.1 vs. 52.2 ± 13.5, p = 0.82) and body mass index (24.3 ± 2.5 vs. 24.0 ± 4.0, p = 0.72) matched normal controls from two major hospitals in China were included in the study. Compared with normal controls, the multivariate analysis revealed that curvature (OR 1.239, 95% CI 1.122–1.369, p < 0.001) and tortuosity (OR 0.002, 95% CI, 0.000–0.083, p = 0.001) were independent predictors of ISMAD occurrence.

Patients with ISMAD exhibited higher levels of curvature and lower levels of tortuosity compared to normal control group.