# Alpha-tocopherol serum concentrations and its relationship with anthropometric, biochemical, dietary and cardiovascular risk parameters

## TL;DR

This study explores how alpha-tocopherol levels relate to body measurements, blood markers, diet, and heart disease risk in adults.

## Contribution

It identifies new associations between alpha-tocopherol and cardiovascular risk factors, including inflammation and cholesterol levels.

## Key findings

- Higher alpha-tocopherol levels correlate with elevated cholesterol markers like non-HDL-c and LDL-c.
- Alpha-tocopherol is linked to lower inflammation markers like hs-CRP.
- Cardiovascular risk scores are positively associated with alpha-tocopherol/total cholesterol ratios.

## Abstract

Alpha-tocopherol is a fat-soluble vitamin with antioxidant properties, capable of reducing oxidative stress and protecting cell membranes from oxidative damage. This vitamin also acts in the prevention of cardiovascular diseases, however research into this relationship is currently limited. This study aimed to assess the relationship between alpha-tocopherol concentrations and anthropometric, biochemical, usual dietary intake, and cardiovascular risk parameters.

A cross-sectional study was conducted to collect sociodemographic, anthropometric, biochemical parameters of 92 adult individuals. Usual dietary intake was estimated with two 24-h recalls (24hR), using the Multiple Source Method. Cardiovascular risk was calculated using the Framingham global risk score (GRS). Alpha-tocopherol was examined by high performance liquid chromatography (HPLC). Multiple linear regression was used to evaluate the relationship between anthropometric, biochemical, usual dietary intake, and cardiovascular risk variables associated with alpha-tocopherol/total cholesterol concentrations.

The studied population presented a mean alpha-tocopherol of 17.80 μmol/L. Total cholesterol, non-HDL-c and LDL-c were significantly higher in individuals with higher serum concentrations of alpha-tocopherol. High-sensitivity C-reactive protein (hs-CRP) was significantly lower in subjects with higher concentrations of alpha-tocopherol. The GRS percentage was 10% for the total population. The multiple linear regression model showed that GRS was positively associated (β = 0.328; 95% CI 0.015, 0.100; p = 0.009) and the conicity index negatively associated (β = −0.290; 95% CI −8.196, −0.728; p = 0.020) with alpha-tocopherol/total cholesterol.

Alpha-tocopherol was positively associated with biochemical and cardiovascular risk parameters, suggesting metabolic alterations that are related to low-grade inflammation resulting from excess weight and increased cardiovascular risk.