# Rapid Progression of a CT-Defined Vulnerable Coronary Plaque: A Multimodality Imaging Case Report

**Authors:** B. S. H. Hagen, P. A. Diemen, M. J. Bom, S. P. Schumacher, A. C. van Rossum, A. Nap, M. P. Opolski, C. J. W. Verouden, I. Danad, P. Knaapen

PMC · DOI: 10.1155/cric/9999700 · Case Reports in Cardiology · 2025-10-16

## TL;DR

This case report shows how a dangerous coronary plaque quickly worsened using CT and angiography.

## Contribution

The study demonstrates rapid plaque progression using multimodal imaging in a single patient.

## Key findings

- Intraplaque neovascularization and hemorrhage were observed in a rapidly progressive plaque.
- Multimodal imaging confirmed the vulnerability and progression of the coronary plaque.
- Serial imaging techniques effectively tracked plaque changes over time.

## Abstract

Rapid progression of vulnerable plaques due to intraplaque neovascularization and hemorrhage is deemed as an important process preceding plaque rupture leading to myocardial infarction. We present a patient with a rapidly progressive vulnerable plaque assessed by means of coronary computed tomography angiography and serial invasive coronary angiography.

## Linked entities

- **Diseases:** myocardial infarction (MONDO:0005068)

## Full-text entities

- **Diseases:** hemorrhage (MESH:D006470), myocardial infarction (MESH:D009203)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12549209/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12549209/full.md

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Source: https://tomesphere.com/paper/PMC12549209